TCID

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Chemical Structure| 30675-13-9 同义名 : 4,5,6,7-Tetrachloroindan-1,3-dione; UCH-L3 Inhibitor
CAS号 : 30675-13-9
货号 : A114208
分子式 : C9H2Cl4O2
纯度 : 98%
分子量 : 283.92
MDL号 : MFCD00239209
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(63.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • UCH

    UCH-L3, IC50:0.6 μM
描述 TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.61mL

3.52mL

1.76mL

35.22mL

7.04mL

3.52mL
参考文献

[1]Martinez-Villarreal J, Garcia Tardon N, et al. Cell surface turnover of the glutamate transporter GLT-1 is mediated by ubiquitination/deubiquitination. Glia. 2012 Sep;60(9):1356-65.

[2]Liu Y, Lashuel HA, et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003 Sep;10(9):837-46.