LY2940094

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Chemical Structure| 1307245-86-8 同义名 : BTRX-246040
CAS号 : 1307245-86-8
货号 : A1001776
分子式 : C22H23ClF2N4O2S
纯度 : 97%
分子量 : 480.96
MDL号 : MFCD31726209
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(83.17 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 LY2940094, also known as BTRX-246040, is a potent, selective and oral nociceptor receptor (NOP receptor) antagonist with high affinity (Ki=0.105 nM) and antagonistic potency (Kb=0.166 nM). LY2940094 reduces ethanol self-administration in animal models[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.40mL

2.08mL

1.04mL

20.79mL

4.16mL

2.08mL
参考文献

[1]Rorick-Kehn LM, et al. A Novel, Orally Bioavailable Nociceptin Receptor Antagonist, LY2940094, Reduces Ethanol Self-Administration and Ethanol Seeking in Animal Models. Alcohol Clin Exp Res. 2016 May;40(5):945-54.