CB-1158-analog

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Chemical Structure| 1345810-21-0 同义名 : CB-1158; Numidargistat; INCB01158 analog; INCB 01158; Arginase inhibitor 2
CAS号 : 1345810-21-0
货号 : A999226
分子式 : C18H27BCl2N2O4
纯度 : 99+%
分子量 : 417.14
MDL号 : N/A
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 CB-1158 is a potent arginase inhibitor. CB-1158 has the potential for anti-tumor activity in renal cell cancer, breast cancer, non-small cell lung cancer, acute myeloid leukemia, and other tumor types where arginase-secreting MDSCs are known to play an immunosuppressive role.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.40mL

0.48mL

0.24mL

11.99mL

2.40mL

1.20mL

23.97mL

4.79mL

2.40mL
参考文献

[1]Melissa Works, Mark Bennett, et al.Abstract 552: Immuno-oncology agent CB-1158 is a potent and selective arginase inhibitor and causes an immune-mediated anti-tumor response. Cancer Res July 15 2016 (76) (14 Supplement) 552; DOI: 10.1158/1538-7445.AM2016-552

[2]Matthew Gross, Jason Chen, et al.Abstract A195: CB-1158 inhibits the immuno-oncology target arginase and causes an immune mediated anti-tumor response. Mol Cancer Ther December 1 2015 (14) (12 Supplement 2) A195.