BVT-14225

产品说明书

Print
Chemical Structure| 376638-65-2 同义名 : -
CAS号 : 376638-65-2
货号 : A998364
分子式 : C16H20ClN3O3S2
纯度 : 98%+
分子量 : 401.93
MDL号 : MFCD25976913
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(261.24 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 The targeted inhibition of 11β-HSD1 leads to reduced blood glucose levels in hyperglycemic mice, highlighting the therapeutic potential of selective 11β-HSD1 inhibitors for addressing diseases with significant unmet medical needs, such as type 2 diabetes, obesity, and metabolic syndrome. BVT-14225 is notably effective in enzyme assays, achieving 90% inhibition at a concentration of 10 μM, and exhibits an IC50 of 52 nM against the human enzyme[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.49mL

0.50mL

0.25mL

12.44mL

2.49mL

1.24mL

24.88mL

4.98mL

2.49mL
参考文献

[1]Vicker N, et al. Novel non-steroidal inhibitors of human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. 2007 May;104(3-5):123-9.