YHO-13351

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Chemical Structure| 1346753-00-1 同义名 : -
CAS号 : 1346753-00-1
货号 : A970502
分子式 : C27H37N3O7S2
纯度 : 97%
分子量 : 579.73
MDL号 : MFCD28900681
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(51.75 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 YHO-13351 is the water-soluble prodrug of YHO-13177, which is a potent and specific inhibitor of BCRP.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.62mL

1.72mL

0.86mL

17.25mL

3.45mL

1.72mL
参考文献

[1]Shishido Y, Ueno S, et al. ABCG2 inhibitor YHO-13351 sensitizes cancer stem/initiating-like side population cells to irinotecan. Anticancer Res. 2013 Apr;33(4):1379-86.

[2]Yamazaki R, Nishiyama Y, et al. Novel acrylonitrile derivatives, YHO-13177 and YHO-13351, reverse BCRP/ABCG2-mediated drug resistance in vitro and in vivo. Mol Cancer Ther. 2011 Jul;10(7):1252-63.