NGI-1
产品说明书
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同义名 : | ML414; N-linked Glycosylation Inhibitor 1 |
| CAS号 : | 790702-57-7 | |
| 货号 : | A956586 | |
| 分子式 : | C17H22N4O3S2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 394.51 | |
| MDL号 : | MFCD06358908 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(266.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | NGI-1, also known as ML414, is a potent oligosaccharyltransferase (OST) inhibitor that directly targets and blocks the function of the OST catalytic subunits STT3A and STT3B[1].NGI-1 effectively reduces viral infectivity without affecting cell viability. NGI-1 blocks N-linked glycosylation of EGFR in lung adenocarcinoma cells and results in altered cellular localisation of the EGFR[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.53mL 0.51mL 0.25mL |
12.67mL 2.53mL 1.27mL |
25.35mL 5.07mL 2.53mL |
| 参考文献 |
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