URB937

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Chemical Structure| 1357160-72-5 同义名 : -
CAS号 : 1357160-72-5
货号 : A950546
分子式 : C20H22N2O4
纯度 : 99%+
分子量 : 354.4
MDL号 : MFCD22987960
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(705.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 URB937 is a peripherally restricted FAAH inhibitor with oral activity and an IC50 value of 26.8 nM. URB937 does not affect FAAH activity in the brain (does not penetrate the blood-brain barrier)[1].URB937 is actively excreted from the CNS by the ATP-binding cassette (ABC) membrane transporter Abcg2[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.82mL

0.56mL

0.28mL

14.11mL

2.82mL

1.41mL

28.22mL

5.64mL

2.82mL
参考文献

[1]Jason R Clapper, et al. Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci. 2010 Oct;13(10):1265-70.

[2]G Moreno-Sanz, et al. Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier. Br J Pharmacol. 2012 Dec;167(8):1620-8.

[3]Rui Li, et al. The Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates Radiation-Induced Lung Injury in a Mouse Model. Inflammation. 2017 Aug;40(4):1254-1263.