AZD2932

产品说明书

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Chemical Structure| 883986-34-3 同义名 : -
CAS号 : 883986-34-3
货号 : A945561
分子式 : C24H25N5O4
纯度 : 99%
分子量 : 447.49
MDL号 : MFCD25977021
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(20.11 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • VEGFR2

    VEGFR-2, IC50:8 nM

  • PDGFRβ

    PDGFRβ, IC50:4 nM

  • c-Kit

    c-Kit, IC50:9 nM
描述 AZD2932 has a potent and balanced profile against PDGFβ, VEGFR-2, Flt-3 and c-Kit. It does not inhibit the various cytochrome P450 isoforms with the worst IC50 being against 2C9 (8.0 μM). AZD2932 has no activity against hERG (IC50=137 μM)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.17mL

2.23mL

1.12mL

22.35mL

4.47mL

2.23mL
参考文献

[1]Plé PA, et al. Discovery of AZD2932, a new Quinazoline Ether Inhibitor with high affinity for VEGFR-2 and PDGFR tyrosine kinases. Bioorg Med Chem Lett. 2012 Jan 1;22(1):262-6.