同义名 :	-
	CAS号 :	85122-21-0
	货号 :	A943808
	分子式 :	C14H12O5
	纯度 :	98+%
	分子量 :	260.24
	MDL号 :	-
	存储条件：	Pure form In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-

生物活性

描述

2-Methoxystypandrone, a natural product isolated and purified from the roots of Polygonum cuspidatum, displays an immunomodulatory effect in a cellular model, specifically inhibits JAK and IKKβ kinase activities, blocks inflammatory responses by impairing NF-κB signaling to limit the inflammation and oxidative stress for preservation of BBB integrity, concomitantly promotes neurodevelopmental protein expression and endogenous neurogenesis through inactivation of GSK3β to enhance β-catenin signaling for upexpression of neuroprotective genes and proteins, and has anti-osteoclastogenic effect, could reflect the block of RANKL-induced association of TRAF6-TAK1 complexes with consequent decrease of IkappaB-mediated NF-kappaB and mitogen-activated protein kinases-mediated c-Fos activation pathways and suppression of NFATc1 and other gene expression, essential for bone resorption.

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.84mL 0.77mL 0.38mL	19.21mL 3.84mL 1.92mL	38.43mL 7.69mL 3.84mL

参考文献

[1]Kuang S, Qi C, et al. 2-Methoxystypandrone inhibits signal transducer and activator of transcription 3 and nuclear factor-κB signaling by inhibiting Janus kinase 2 and IκB kinase. Cancer Sci. 2014 Apr;105(4):473-80. [2]Chern CM, Wang YH, et al. 2-Methoxystypandrone ameliorates brain function through preserving BBB integrity and promoting neurogenesis in mice with acute ischemic stroke. Biochem Pharmacol. 2014 Feb 1;87(3):502-14.