LY2886721

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Chemical Structure| 1262036-50-9 同义名 : β-Secretase
CAS号 : 1262036-50-9
货号 : A943144
分子式 : C18H16F2N4O2S
纯度 : 99%+
分子量 : 390.41
MDL号 : MFCD22124078
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 16 mg/mL(40.98 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 LY2886721 is an BACE inhibitor used for the treatment of Alzheimer's Disease.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.56mL

0.51mL

0.26mL

12.81mL

2.56mL

1.28mL

25.61mL

5.12mL

2.56mL
参考文献

[1]May PC, Willis BA, et al. The potent BACE1 inhibitor LY2886721 elicits robust central Aβ pharmacodynamic responses in mice, dogs, and humans. J Neurosci. 2015 Jan21;35(3):1199-210.

[2]Townsend M. When will Alzheimer's disease be cured? A pharmaceutical perspective. J Alzheimers Dis. 2011;24 Suppl 2:43-52.