SecinH3
产品说明书
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同义名 : | - |
| CAS号 : | 853625-60-2 | |
| 货号 : | A923399 | |
| 分子式 : | C24H20N4O4S | |
| 纯度 : | 99%+ | |
| 分子量 : | 460.51 | |
| MDL号 : | MFCD10687099 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 125 mg/mL(271.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | SecinH3 is a selective cytohesin inhibitor for hCyh2, hCyh1, mCyh3, hCyh3, drosophila steppke, and yGea2-S7 with IC50 of 2.4 μM, 5.4 μM, 5.4 μM, 5.6 μM, 5.6 μM, and 65 μM respectively. SecinH3 almost completely blocks the insulin-dependent transcriptional repression of IGFBP1 with an IC50 of 2.2 μM. Insulin-stimulated translocation of ARF6 to the plasma membrane is also inhibited by SecinH3. SecinH3-treated mice show increased expression of gluconeogenic genes, reduced expression of glycolytic, fatty acid and ketone body metabolism genes in the liver, reduced liver glycogen stores, and a compensatory increase in plasma insulin[3]. SecinH3, a cytohesin inhibitor, has neuroprotective effects against mutant SOD1 toxicity. SecinH3 was demonstrated to successfully attenuate the TDP-43 (transactivating response region DNA binding protein 43) Q331K-induced neuronal toxicity by suppressing ER (endoplasmic reticulum) stress-mediated apoptosis and enhancing the autophagic flux[4]. SecinH3 can significantly inhibit the cytohesins and then relieve the lung injury induced by the sepsis of rats[5]. Treating mice bearing H460 xenografts with SecinH3 showed the antiproliferative and pro-apoptotic effect of SecinH3 in vivo[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.17mL 0.43mL 0.22mL |
10.86mL 2.17mL 1.09mL |
21.72mL 4.34mL 2.17mL |
| 参考文献 |
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