Febrifugine

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Chemical Structure| 24159-07-7 同义名 : 常山乙素 ;NSC 315535; (+)-Febrifugine
CAS号 : 24159-07-7
货号 : A920007
分子式 : C16H19N3O3
纯度 : 98%
分子量 : 301.34
MDL号 : N/A
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(82.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Febrifugine, a natural product isolated and purified from the roots of Dichroa febrifuga, is an effective coccidiostat, possesses schizonticide property, shows high degree of antimalarial activity but use limited by toxicity .
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.32mL

0.66mL

0.33mL

16.59mL

3.32mL

1.66mL

33.19mL

6.64mL

3.32mL
参考文献

[1]Herman JD, Pepper LR, et al. The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs. Sci Transl Med. 2015 May 20;7(288):288ra77.

[2]Sen D, Chatterjee TK. Pharmacophore modeling and 3D quantitative structure-activity relationship analysis of febrifugine analogues as potent antimalarial agent. J Adv Pharm Technol Res. 2013 Jan;4(1):50-60.