A2793

产品说明书

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Chemical Structure| 88349-90-0 同义名 : Ethyl [(5-Chloroquinolin-8-yl)oxy]acetate
CAS号 : 88349-90-0
货号 : A919855
分子式 : C13H12ClNO3
纯度 : 99%+
分子量 : 265.69
MDL号 : MFCD04275530
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(395.19 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 A2793 is a potent dual inhibitor of TWIK-related acid-sensitive K+ channels (TASK)-1 and TRESK, with an IC50 of 6.8 μM for mTRESK. A2764 exhibits greater selectivity for TRESK and only moderately affects TREK-1 and TALK-1 [1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.76mL

0.75mL

0.38mL

18.82mL

3.76mL

1.88mL

37.64mL

7.53mL

3.76mL
参考文献

[1]Miklós Lengyel, et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K 2P 18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660.