Desipramine HCl
产品说明书
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同义名 : | 盐酸地昔帕明 ;Desipramine Hydrochloride; Desmethylimipramine; NSC-114901; JB-8181; G-35020; EX-4355; Norimipramine |
| CAS号 : | 58-28-6 | |
| 货号 : | A914953 | |
| 分子式 : | C18H23ClN2 | |
| 纯度 : | 98% | |
| 分子量 : | 302.84 | |
| MDL号 : | MFCD00058108 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(346.72 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(330.21 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Desipramine HCl is an inhibitor of norepinephrine transporter (NET), 5-HT transporter (SERT) and dopamine transporter (DAT) with Kis of 4, 61 and 78,720 nM, respectively[1]. Treatment of rats with 15 mg/kg per day desipramine reduced NET (norepinephrine transporter) expression, measured by (3)H-nisoxetine binding and SDS-PAGE/immunoblotting, in cerebral cortex and hippocampus and reduced the time of immobility in the forced-swim test. The antidepressant-like effect on forced-swim behavior was evident 2 days following discontinuation of desipramine treatment when plasma and brain levels of desipramine and its major metabolite desmethyldesipramine were not detectable[2]. Fewer subjects reported adverse events following treatment with desipramine alone than when receiving desipramine with cinacalcet (33 versus 86%), the most frequent of which (nausea and headache) have been reported for patients treated with either desipramine or cinacalcet[3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01179828 | Low Back Pain | Phase 3 | Completed | - | Switzerland ... 展开 >> Andreas Siegenthaler Dep. of Anesthesiolgy and Pain therapy, Bern University Hospital, Switzerland, 3010 Bern 收起 << |
| NCT00704860 | Major Depression | Phase 4 | Completed | - | Canada, Ontario ... 展开 >> University of Ottawa Institute of Mental Health Research Ottawa, Ontario, Canada, K1Z 7K4 收起 << |
| NCT00000241 | Substance-Related Disorders | Phase 2 | Completed | - | United States, California ... 展开 >> Friends Research Institute Los Angeles, California, United States, 90025 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.30mL 0.66mL 0.33mL |
16.51mL 3.30mL 1.65mL |
33.02mL 6.60mL 3.30mL |
| 参考文献 |
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