STING agonist-1

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Chemical Structure| 702662-50-8 同义名 : G10
CAS号 : 702662-50-8
货号 : A910101
分子式 : C21H16ClFN2O3S
纯度 : 99%+
分子量 : 430.88
MDL号 : MFCD04062826
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 80 mg/mL(185.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 STING is a pattern recognition receptor of cyclic dinucleotides and an innate immune adaptor protein. STING agonist-1 is a human-specific STING agonist with antiviral activity. It inhibited replication of Chikungunya Virus and Venezuelan Equine Encephalitis Virus with IC90 values 8.01μM of 24.57μM, respectively. Exposing human fibroblasts to STING agonist-1 (100μM) led to transcription of cellular genes triggered by IRF3/IFN-dependent signaling, but not NF-κB-dependent signaling. STING agonist-1 at a concentration of 100μM also induced IRF3 phosphorylation and elicited anti-alphaviral activity in cells lacking IPS1. In human peripheral blood mononuclear cells, treatment with STING agonist-1 (25–100μM) for 8 hours induced innate antiviral mRNA expression, including IFIT1, IFIT2, IFNβ, ISG15, OAS, and Viperin[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.32mL

0.46mL

0.23mL

11.60mL

2.32mL

1.16mL

23.21mL

4.64mL

2.32mL
参考文献

[1]Sali TM, Pryke KM, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015 Dec 8;11(12):e1005324.

[2]Sali TM, Pryke KM, Abraham J, et al. Characterization of a Novel Human-Specific STING Agonist that Elicits Antiviral Activity Against Emerging Alphaviruses. PLoS Pathog. 2015;11(12):e1005324.