Specnuezhenide

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Chemical Structure| 39011-92-2 同义名 : Nuezhenide; (8E)-Nuezhenide; Nuzhenide
CAS号 : 39011-92-2
货号 : A904680
分子式 : C12H22O2
纯度 : 99%+
分子量 : 686.66
MDL号 : MFCD20274720
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(364.08 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Nuezhenide (Specneuzhenide) is a phenol glycoside isolated from Ligustrum sinense. Nuezhenide (Specneuzhenide) possesses anti-tumor activity[3]. NZD (Nuezhenide) exhibited anti-inflammatory activity and reduced the release of inflammatory cytokines such as nitrite, TNF-α, and IL-6. NZD suppressed the expression of the phosphorylated proteins like IKKα/β, IκBα, and p65. Besides, the flow cytometry results indicated that NZD inhibited the levels of ROS, NO, and Ca2+ in LPS-stimulated RAW264.7 cells. NZD reversed LPS-induced MMP (mitochondrial membrane potential) loss. Furthermore, NZD suppressed LPS-induced NF-B/p65 translocation from the cytoplasm into the nucleus[4]. SPE (Specneuzhenide) could inhibit the decrease of body weight compared with the model group, and trigger improvement in the renal index. High dose and low dose SPE could trigger a significant decrease in serum IL1β, IL-6 and TNF-α compared with the model group. SPE could attenuate the glomerular lesions in DN rats. SPE induced up-regulation of podocin and CD2AP. SPE showed protective effects on renal injury through attenuating the pathological injury and urine protein[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.46mL

0.29mL

0.15mL

7.28mL

1.46mL

0.73mL

14.56mL

2.91mL

1.46mL
参考文献

[1]Ben Mansour A, Porter EA, et al. Phenolic profile characterization of Chemlali olive stones by liquid chromatography-ion trap mass spectrometry. J Agric Food Chem. 2015 Feb 25;63(7):1990-5.

[2]Sung SH, Kim ES, et al. A new neuroprotective compound of Ligustrum japonicum leaves. Planta Med. 2006 Jan;72(1):62-4.

[3]Chen L, Du J, Dai Q, Zhang H, Pang W, Hu J. Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. Eur J Med Chem. 2014 Aug 18;83:294-306

[4]Wang QQ, Han S, Li XX, Yuan R, Zhuo Y, Chen X, Zhang C, Chen Y, Gao H, Zhao LC, Yang S. Nuezhenide Exerts Anti-Inflammatory Activity through the NF-κB Pathway. Curr Mol Pharmacol. 2021;14(1):101-111

[5]Yin J, Jiang J, Wang H, Lu G. Protective Effects of Specneuzhenide on Renal Injury in Rats with Diabetic Nephropathy. Open Med (Wars). 2019 Oct 6;14:740-747