Sulfisomidin

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Chemical Structure| 515-64-0 同义名 : 磺胺二甲基异嘧啶 ;Sulfaisodimidine; Sulfamethin; Sulfisomidine
CAS号 : 515-64-0
货号 : A902129
分子式 : C12H14N4O2S
纯度 : 99%+
分子量 : 278.33
MDL号 : MFCD00010567
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(377.25 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Sulfisomidin (Sulfaisodimidine) is an orally active short-acting sulfonamide antibacterial. Sulfisomidine is a sulfonamide consisting of pyrimidine having methyl substituents at the 2- and 6-positions and a 4-aminobenzenesulfonamido group at the 4-position. It has a role as an antiinfective agent. It is a member of pyrimidines, a sulfonamide and a sulfonamide antibiotic.It derives from a sulfanilamide[1]. About 70% of sulphasomidine (0.1g./kg.) is excreted mainly unchanged in the urine by these species in 24hr.; less than 15% of the dose is acetylated and there is no marked species difference in the fate of this drug ( in man, rhesus monkey, rabbit and rat). Although sulphasomidine is poorly acetylated in vivo, it is acetylated in vitro at rates comparable with those of the other two drugs[1]. Moreover, the risk of therapy failure due to low blood concentrations of sulfaisodimidine should not be greater when the drug is given in a dosage of 2 g twice daily than when it is administered in the conventional way (1 g four times daily)[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.59mL

0.72mL

0.36mL

17.96mL

3.59mL

1.80mL

35.93mL

7.19mL

3.59mL
参考文献

[1]Bridges JW, Walker SR, Williams RT. Species differences in the metabolism and excretion of sulphasomidine and sulphamethomidine. Biochem J. 1969 Jan;111(2):173-9

[2]Melander A, Bitzén PO, Olsson S. Therapeutic equivalence of sulfaisodimidine 2 g twice daily and 1 g four times daily in lower urinary tract infections. Acta Med Scand. 1982;211(5):361-4