N-Methylcytisine

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Chemical Structure| 486-86-2 同义名 : N-甲基野靛碱 ;Caulophylline; N-Me-cy; BRN-0012448; NMC; Caulophyllin
CAS号 : 486-86-2
货号 : A900570
分子式 : C12H16N2O
纯度 : 99%+
分子量 : 204.27
MDL号 : MFCD00211091
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 115 mg/mL(562.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(489.55 mM)，配合低频超声助溶
生物活性
描述 N-Methylcytisine(NMC), a tricyclic quinolizidine alkaloid, exerts hypoglycaemic, analgesic and anti-inflammatory activities. Oral administration (1, 4 and 16 mg/kg) of NMC attenuated the DSS(dextran sulfate sodium)-induced clinical symptoms and pathological damage. In addition, NMC treatment significantly reduced myeloperoxidase activity and level of pro-inflammatory cytokines. NMC blocked the activation of NF-κB by inhibiting IκB and IKK phosphorylation[3]. N-methylcytisine is a selective ligand of nicotinic receptors of acetylcholine in the central nervous system and has a high affinity (Kd = 50 nM) to nicotinic acetylcholine receptors (nAChR) from squid optical ganglia[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.90mL

0.98mL

0.49mL

24.48mL

4.90mL

2.45mL

48.95mL

9.79mL

4.90mL
参考文献

[1]Wang S, Wu H, et al. Determination of N-methylcytisine in rat plasma by UPLC-MS/MS and its application to pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 May 15;990:118-24.

[2]Pliashkevich IuG, Demushkin VP. [N-methylcytisine--a selective ligand of nicotinic receptors of acetylcholine in the CNS] . Biull Eksp Biol Med. 1987 Dec;104(12):690-2. Russian.

[3]Jiao YF, Lu M, Zhao YP, Liu N, Niu YT, Niu Y, Zhou R, Yu JQ. N-Methylcytisine Ameliorates Dextran-Sulfate-Sodium-Induced Colitis in Mice by Inhibiting the Inflammatory Response. Molecules. 2018 Feb 25;23(3):510

[4]Terada M, Ishii AI, Kino H, Sano M. Studies on chemotherapy of parasitic helminths (VIII). Effects of some possible neurotransmitters on the motility of Angiostrongylus cantonensis. Jpn J Pharmacol. 1982 Aug;32(4):643-53