NVP-BSK805 2HCl

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Chemical Structure| 1942919-79-0 同义名 : NVP-BSK805 (hydrochloride); BSK805; NVP-BSK805 dihydrochloride
CAS号 : 1942919-79-0
货号 : A883782
分子式 : C27H30Cl2F2N6O
纯度 : 95%
分子量 : 563.47
MDL号 : MFCD22420810
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(88.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • JAK1

    JAK1, IC50:31.63 nM

  • JAK3

    JAK3, IC50:18.68 nM

  • Tyk2

    TYK2, IC50:10.76 nM

  • JAK2

    JAK2, IC50:~0.5 nM
描述 NVP-BSK805 dihydrochloride is a potent and selective ATP-competitive JAK2 inhibitor with IC50 of 0.5 nM and > 20-fold selectivity towards JAK1, JAK3 and TYK2.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.77mL

0.35mL

0.18mL

8.87mL

1.77mL

0.89mL

17.75mL

3.55mL

1.77mL
参考文献

[1]Rubert J, Qian Z, et al. Bim and Mcl-1 exert key roles in regulating JAK2V617F cell survival. BMC Cancer. 2011 Jan 19;11:24.

[2]Baffert F, Regnier CH, et al. Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805. Mol Cancer Ther. 2010 Jul;9(7):1945-55.