GGTI298

产品说明书

Print
Chemical Structure| 180977-44-0 同义名 : -
CAS号 : 180977-44-0
货号 : A882713
分子式 : C27H33N3O3S
纯度 : 98+%
分子量 : 479.63
MDL号 : MFCD02683591
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 GGTI298 is a CAAZ peptidomimetic geranylgeranyltransferase I (GGTase I) inhibitor, strongly inhibiting the processing of geranylgeranylated Rap1A with little effect on processing of farnesylated Ha-Ras, withIC50values of 3 and > 10 μM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.08mL

0.42mL

0.21mL

10.42mL

2.08mL

1.04mL

20.85mL

4.17mL

2.08mL
参考文献

[1]Sheikh IA, Koley H, et al. The Epac1 signaling pathway regulates Cl- secretion via modulation of apical KCNN4c channels in diarrhea. J Biol Chem. 2013 Jul 12;288(28):20404-15.

[2]Chen S, Fu L, et al. Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis. Mol Cancer. 2010 Jan 29;9:23.