Icilin
产品说明书
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同义名 : | AG-3-5 |
| CAS号 : | 36945-98-9 | |
| 货号 : | A881912 | |
| 分子式 : | C16H13N3O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 311.29 | |
| MDL号 : | MFCD01689072 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 55 mg/mL(176.68 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Icilin is an agonist of nonselective cation channel TRPM8, with antiproliferative activity. TRPM8 is a cation channel activated by cold temperatures and the chemical stimuli menthol and icilin[3]. The synthetic supercooling drug, icilin, and its primary receptor target, the cation channel transient receptor potential (TRP) melastatin-8 (TRPM8), have been described as potent negative regulators of inflammation in the colon. In vitro, icilin potently inhibited the proliferation of murine and human CD4+ T cells, with the peripheral expansion of autoantigen-restricted T cells similarly diminished by the administration of icilin in mice[4]. Rats injected with icilin (0.5, 1, 2.5, 5mg/kg, i.p.) displayed dose-related WDS (wet-dog shakes) that were inhibited by pretreatment with a fixed dose of clonidine (0.15 mg/kg, s.c.). alpha(2)-adrenoceptor activation inhibits shaking induced by icilin and that increases in peripheral, as well as central, alpha(2)-adrenoceptor signaling oppose the behavioral stimulant effect of icilin[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.21mL 0.64mL 0.32mL |
16.06mL 3.21mL 1.61mL |
32.12mL 6.42mL 3.21mL |
| 参考文献 |
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