Ethoxzolamide

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Chemical Structure| 452-35-7 同义名 : Redupresin; L-643786; 6-Ethoxyzolamide; Ethoxzolamide, Ethoxyzolamide, Ethoxazolamide, Cardrase, Ethamide; PNU-4191
CAS号 : 452-35-7
货号 : A876758
分子式 : C9H10N2O3S2
纯度 : 99%+
分子量 : 258.32
MDL号 : MFCD00057089
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(406.48 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Ethoxzolamide (ETZ) leads to more than 90% inhibition of GFP reporter fluorescence in macrophages infected with M. tuberculosis. Additionally, in a 9-day macrophage survival assay, ETZ significantly curtails the intracellular growth of M. tuberculosis[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.87mL

0.77mL

0.39mL

19.36mL

3.87mL

1.94mL

38.71mL

7.74mL

3.87mL
参考文献

[1]Maren TH, et al. Relations among IOP reduction, ocular disposition and pharmacology of the carbonic anhydrase inhibitor ethoxzolamide. Exp Eye Res. 1992 Jul;55(1):73-9.

[2]Benjamin K. Johnson, et al. The Carbonic Anhydrase Inhibitor Ethoxzolamide Inhibits theMycobacterium tuberculosis PhoPR Regulon and Esx-1 Secretion and Attenuates Virulence. Antimicrob Agents Chemother. 2015 Aug; 59(8): 4436–4445.