Jatrophane 2

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Chemical Structure| 210108-86-4 同义名 : -
CAS号 : 210108-86-4
货号 : A876527
分子式 : C39H50O15
纯度 : 98+%
分子量 : 758.81
MDL号 : -
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Jatrophane 2, a natural product isolated and purified from the branches of Jatropha carcas L., exhibits significant antifeedant activity against a generalist plant-feeding insect, the cotton bollworm (Helicoverpa armigera), and demonstrates the most powerful inhibition of P-gp, higher than R(+)-verapamil and tariquidar in colorectal multi-drug resistant (MDR) cells (DLD1-TxR).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.32mL

0.26mL

0.13mL

6.59mL

1.32mL

0.66mL

13.18mL

2.64mL

1.32mL
参考文献

[1]Esposito M, Nim S, et al. Evaluation of Jatrophane Esters from Euphorbia spp. as Modulators of Candida albicans Multidrug Transporters. J Nat Prod. 2017 Feb 24;80(2):479-487.

[2]Esposito M, Nothias LF, et al. Euphorbia dendroides Latex as a Source of Jatrophane Esters: Isolation, Structural Analysis, Conformational Study, and Anti-CHIKV Activity. J Nat Prod. 2016 Nov 23;79(11):2873-2882.