ASP3026

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Chemical Structure| 1097917-15-1 同义名 : -
CAS号 : 1097917-15-1
货号 : A874603
分子式 : C29H40N8O3S
纯度 : 99%+
分子量 : 580.74
MDL号 : MFCD21609265
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(30.99 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • ALK

    ALK, IC50:3.5 nM
描述 ASP3026 is a potent, selective, and orally administered inhibitor of anaplastic lymphoma kinase (ALK). It promotes apoptosis in tumor cells and is applicable in non-small cell lung cancer (NSCLC) research[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.72mL

0.34mL

0.17mL

8.61mL

1.72mL

0.86mL

17.22mL

3.44mL

1.72mL
参考文献

[1]Discovery of Iikubo K, et, al. N-{2-Methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propane-2-sulfonyl)phenyl]-1,3,5-triazine-2,4-diamine (ASP3026), a Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor. Chem Pharm Bull (Tok

[2]George SK, et, al. The ALK inhibitor ASP3026 eradicates NPM-ALK⁺ T-cell anaplastic large-cell lymphoma in vitro and in a systemic xenograft lymphoma model. Oncotarget. 2014 Jul 30;5(14):5750-63.