Torcetrapib

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Chemical Structure| 262352-17-0 同义名 : CP-529414; (–)-Torcetrapib
CAS号 : 262352-17-0
货号 : A869440
分子式 : C26H25F9N2O4
纯度 : 95%
分子量 : 600.47
MDL号 : MFCD08063631
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(174.86 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • CETP

    CETP, IC50:37 nM
描述 Torcetrapib is a CETP inhibitor with IC50 of 37 nM, elevates HDL-C and reduces nonHDL-C in plasma.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00136981 Hypercholesterolemia, Familial... 展开 >> Hyperlipidemia 收起 << Phase 3 Completed - -
NCT00134173 Coronary Disease ... 展开 >> Coronary Arteriosclerosis Hyperlipidemia 收起 << Phase 3 Completed - -
NCT00134238 Mixed Hyperlipidemia Phase 3 Terminated - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.67mL

0.33mL

0.17mL

8.33mL

1.67mL

0.83mL

16.65mL

3.33mL

1.67mL
参考文献

[1]Hu X, Dietz JD, et al. Torcetrapib induces aldosterone and cortisol production by an intracellular calcium-mediated mechanism independently of cholesteryl ester transfer protein inhibition. Endocrinology. 2009 May;150(5):2211-9.

[2]Clark RW, Sutfin TA, et al. Raising high-density lipoprotein in humans through inhibition of cholesteryl ester transfer protein: an initial multidose study of torcetrapib. Arterioscler Thromb Vasc Biol. 2004 Mar;24(3):490-7.