DM1-SMe

产品说明书

Print
Chemical Structure| 138148-68-2 同义名 : -
CAS号 : 138148-68-2
货号 : A866930
分子式 : C36H50ClN3O10S2
纯度 : 98%+
分子量 : 784.38
MDL号 : MFCD28400100
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(133.86 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 DM1-SMe, the unconjugated Maytansinoid present in IMGN901, exhibits significantly enhanced potency—approximately 3-10 times greater—than its progenitor compound, Maytansine. The IC50 values for DM1-SMe span from 0.003 to 0.01 nM across various human tumor cell lines[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.37mL

1.27mL

0.64mL

12.75mL

2.55mL

1.27mL
参考文献

[1]Wood AC, et al. Initial testing (Stage 1) of the antibody-maytansinoid conjugate, IMGN901 (Lorvotuzumab mertansine), by the pediatric preclinical testing program. Pediatr Blood Cancer. 2013;60(11):1860-1867.