RS-MCPG
产品说明书
 |
同义名 : | alpha-MCPG; (RS)-MCPG |
| CAS号 : | 146669-29-6 | |
| 货号 : | A863113 | |
| 分子式 : | C10H11NO4 | |
| 纯度 : | 95% | |
| 分子量 : | 209.2 | |
| MDL号 : | MFCD00210205 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 5 mg/mL(23.9 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 1M NaOH: 100 mg/mL(478.01 mM)，配合低频超声，并调节pH至10 |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | (RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG (alpha-MCPG; 500 μM) blocks the TBS-induced shifts in EGABA in either juvenile or neonatal neurons[2]. Superfusion of MCPG (500 microM) significantly reduced the amplitude of evoked EPSPs(excitatory postsynaptic potentials)[3]. Frequency-dependent depression of EPSC amplitudes occurs independent of endogenous activation of MCPG-sensitive mGluRs in cultured hippocampal neurons[4]. (RS)-MCPG which had no effect on locomotor activity when given to saline pre-exposed rats induced significantly higher locomotor activity in AMPH (amphetamine) compared to saline pre-exposed rats[5]. Rats were trained on a spatial alternation task in a Y-maze with footshock reinforcement, and MCPG (0.0208 mg) was injected intracerebroventricularly prior to training and/or retention test. Animals injected pre-training are clearly impaired in retention, whereas preretention application was without effect. dditionally, MCPG at the same concentration completely blocks a potentiation at perforant path/dentate gyrus synapses in vivo[6]. Moreover, (RS)-alpha-methyl-4-carboxyphenylglycine (MCPG), blocks Y-maze spatial alternation learning[7]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.78mL 0.96mL 0.48mL |
23.90mL 4.78mL 2.39mL |
47.80mL 9.56mL 4.78mL |
| 参考文献 |
|---|