Vasicine

产品说明书

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Chemical Structure| 6159-55-3 同义名 : Peganine
CAS号 : 6159-55-3
货号 : A855860
分子式 : C11H12N2O
纯度 : 98+%
分子量 : 188.23
MDL号 : MFCD09028068
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(451.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Vasicine, a natural product isolated and purified from the leaves of Adhatoda vasica, is a potential cholinesterase inhibitor in development for treatment of Alzheimer's disease, and can regulate the inflammatory reaction.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.31mL

1.06mL

0.53mL

26.56mL

5.31mL

2.66mL

53.13mL

10.63mL

5.31mL
参考文献

[1]Liu W, Shi X, et al. In vitro and in vivo metabolism and inhibitory activities of vasicine, a potent acetylcholinesterase and butyrylcholinesterase inhibitor. PLoS One. 2015 Apr 7;10(4):e0122366.

[2]Shahwar D, Raza MA, et al. Enzyme inhibition, antioxidant and antibacterial potential of vasicine isolated from Adhatoda vasica Nees. Pak J Pharm Sci. 2012 Jul;25(3):651-6.