Telotristat ethyl

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Chemical Structure| 1033805-22-9 同义名 : LX1032; Lx1606
CAS号 : 1033805-22-9
货号 : A855563
分子式 : C27H26ClF3N6O3
纯度 : 99%+
分子量 : 574.98
MDL号 : MFCD18251583
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 95 mg/mL(165.22 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 LX1606 is an orally-delivered inhibitor of tryptophan hydroxylase that reduces serotonin production.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.74mL

0.35mL

0.17mL

8.70mL

1.74mL

0.87mL

17.39mL

3.48mL

1.74mL
参考文献

[1]Tamas Oravecz, et al. LX1606 (aka LX1032), a Novel Inhibitor of Serotonin Synthesis, Alleviates Development of Inflammatory Bowel Disease in a Preclinical Model.

[2]Margolis, K.G., et al., Pharmacological reduction of mucosal but not neuronal serotonin opposes inflammation in mouse intestine. Gut, 2013.