Adipic acid
产品说明书
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同义名 : | Hexanedioic acid |
| CAS号 : | 124-04-9 | |
| 货号 : | A855080 | |
| 分子式 : | C6H10O4 | |
| 纯度 : | 95% | |
| 分子量 : | 146.14 | |
| MDL号 : | MFCD00004420 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(718.48 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 2.5 mg/mL(17.11 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Adipic acid is the most industrially important dicarboxylic acid as it is a key monomer in the synthesis of nylon. Adipic acid is obtained via a chemical process that relies on petrochemical precursors and releases large quantities of greenhouse gases[2]. Enoate reductase from Clostridium acetobutylicum (CaER), an oxygen-sensitive reductase, was demonstrated to have in vivo enzyme activity of converting cis,cis-muconic acid to adipic acid under microaerobic condition. Engineered Escherichia coli strains were constructed to express the whole pathway and accumulated 5.8 ± 0.9 mg/L adipic acid from simple carbon sources[3]. Yeasts and A. niger were found to tolerate substantially higher concentrations of adipic acid than bacteria, and were less affected by the undissociated form of adipic acid than bacteria. The yeast exhibiting the highest tolerance to adipic acid was Candida viswanathii, showing a reduction in maximum specific growth rate of no more than 10-15% at the highest concentration of adipic acid tested and the tolerance was not dependent on the dissociation state of the adipic acid[4]. Moreover, the increase in adipic acid concentration was significantly and indirectly correlated with the severity of the deficit in socialization and communication skills in children with an ASD (autism spectrum disorders ) [5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
6.84mL 1.37mL 0.68mL |
34.21mL 6.84mL 3.42mL |
68.43mL 13.69mL 6.84mL |
| 参考文献 |
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