RO5263397

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Chemical Structure| 1357266-05-7 同义名 : -
CAS号 : 1357266-05-7
货号 : A839796
分子式 : C10H11FN2O
纯度 : 95%
分子量 : 194.21
MDL号 : MFCD28405323
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(1287.3 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 RO5263397 is a potent, selective and orally active TAAR1 agonist with EC50s of 17 and 35 nM for human TAAR1 and rat TAAR1, respectively. RO5263397 modulates wakefulness and EEG spectral composition, and possesses antidepressant-like effects[1][2][3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.15mL

1.03mL

0.51mL

25.75mL

5.15mL

2.57mL

51.49mL

10.30mL

5.15mL
参考文献

[1]Galley G, et al. Discovery and Characterization of 2-Aminooxazolines as Highly Potent, Selective, and Orally Active TAAR1 Agonists.ACS Med Chem Lett. 2015 Dec 30;7(2):192-7.

[2]Schwartz MD, et al. Trace Amine-Associated Receptor 1 Regulates Wakefulness and EEG Spectral Composition.Neuropsychopharmacology. 2017 May;42(6):1305-1314.

[3]Espinoza S, et al. Biochemical and Functional Characterization of the Trace Amine-Associated Receptor 1 (TAAR1) Agonist RO5263397.Front Pharmacol. 2018 Jun 21;9:645.