Propranolol HCl

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Chemical Structure| 318-98-9 同义名 : (±)-Propranolol(hydrochloride); AY-64043; NSC 91523; ICI-45520; Propranolol hydrochloride
CAS号 : 318-98-9
货号 : A835168
分子式 : C16H22ClNO2
纯度 : 99%
分子量 : 295.8
MDL号 : MFCD00012558
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(490.19 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(101.42 mM)，配合低频超声助溶
生物活性
靶点

  • β-adrenergic receptor

    β-adrenergic receptor, IC50:12 nM
描述 Propranolol hydrochloride is a competitive non-selective beta-adrenergic receptors inhibitor with IC50 of 12 nM.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03388957 Extrusion of Tooth Not Applicable Recruiting February 2019 Syrian Arab Republic ... 展开 >> Department of Peadodontics, University of Damascus Dental School Recruiting Damascus, Syrian Arab Republic, DM20AM18 Contact: Mohamed Altinawi, DDS MSc PhD    00963955358197    mohamedaltinawi@gmail.com    Principal Investigator: Omar Abu Bakr, DDS 收起 <<
NCT01000779 Non Cirrhotic Portal Hypertens... 展开 >>ion 收起 << Phase 3 Completed - India ... 展开 >> Department of Gastroenterology, GB Pant Hospital, New Delhi, Delhi, India, 110002 收起 <<
NCT01333150 Temporomandibular Joint Disord... 展开 >>ers Myofascial Temporomandibular Disorders 收起 << Not Applicable Unknown September 2012 Denmark ... 展开 >> Section of Clinical Oral Physiology, Aarhus University Recruiting Aarhus C, Denmark, 8000 Contact: Karina H. Bendixen, PhD fellow    +004587168259    karina.bendixen@odontologi.au.dk    Principal Investigator: Peter Svensson, DDS, PhD, Dr.Odont.          Sub-Investigator: Karina H. Bendixen, DDS, PhD fellow          Section of Clinical Oral Physiology,Department of Dentistry,HEALTH. Aarhus University Recruiting Aarhus, Denmark, 8000 Sub-Investigator: Karina Bendixen, DDS, PhD fellow 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.38mL

0.68mL

0.34mL

16.90mL

3.38mL

1.69mL

33.81mL

6.76mL

3.38mL
参考文献

[1]Glennon RA, Dukat M, et al. The binding of propranolol at 5-hydroxytryptamine1D beta T355N mutant receptors may involve formation of two hydrogen bonds to asparagine. Mol Pharmacol. 1996 Jan;49(1):198-206.