Z-VAD-FMK

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Chemical Structure| 161401-82-7 同义名 : Z-Val-Ala-Asp-(OH)-Fluoromethyl Ketone; Caspase Inhibitor VI; Z-VAD(OH)-FMK
CAS号 : 161401-82-7
货号 : A834991
分子式 : C21H28FN3O7
纯度 : 99%+
分子量 : 453.46
MDL号 : MFCD00016489
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(231.55 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • Caspase
描述 Z-VAD-FMK, known as Z-VAD(OH)-FMK, is a renowned pan-caspase inhibitor, remarkable for its specificity in that it does not inhibit the activity of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) even at concentrations up to 440 μM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.03mL

2.21mL

1.10mL

22.05mL

4.41mL

2.21mL
参考文献

[1]Davies CW, et al. The co-crystal structure of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) with a tripeptide fluoromethyl ketone (Z-VAE(OMe)-FMK). Bioorg Med Chem Lett. 2012 Jun 15;22(12):3900-4.

[2]Liu HR, et al. Antiproliferative activity of the total saponin of Solanum lyratum Thunb in Hela cells by inducing apoptosis. Pharmazie. 2008 Nov;63(11):836-42.