Carnosol

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Chemical Structure| 5957-80-2 同义名 : NSC 39143
CAS号 : 5957-80-2
货号 : A833913
分子式 : C20H26O4
纯度 : 99%+
分子量 : 330.42
MDL号 : MFCD02752467
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(151.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Carnosol is a potent Ribosomal S6 Kinase (RSK2) inhibitor that could be useful for treating gastric cancer, with an IC50 of ~5.5 μM. Carnosol reduced anchorage-dependent and -independent gastric cancer growth by inhibiting the RSKs-CREB signaling pathway. Carnosol increased the G2/M phase and decreased S phase cell cycle and also induced apoptosis through the activation of caspases 9 and 7 and inhibition of Bcl-xL expression. Moreover, oral administration of carnosol suppressed patient-derived gastric tumor growth in an in vivo mouse model[3]. Non-cytotoxic concentrations of carnosol inhibited the migration and invasion of MDA-MB-231 cells in wound healing and matrigel invasion assays. Carnosol significantly and markedly suppressed tumor growth and metastasis of breast cancer xenografts[4]. Carnosol stimulated glucose uptake in L6 myotubes in a dose- and time-dependent manner, did not affect Akt, increased AMPK (AMP-activated kinase) phosphorylation and plasma membrane GLUT4 levels[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.03mL

0.61mL

0.30mL

15.13mL

3.03mL

1.51mL

30.26mL

6.05mL

3.03mL
参考文献

[1]Kracun-Kolarevic M, Dmitrovic S, et al. Influence of sodium salicylate on rosmarinic acid, carnosol and carnosic acid accumulation by Salvia officinalis L. shoots grown in vitro. Biotechnol Lett. 2015 Aug;37(8):1693-701.

[2]Zhai C, Liu Q, et al. Identification of natural compound carnosol as a novel TRPA1 receptor agonist. Molecules. 2014 Nov 14;19(11):18733-46.

[3]Wang L, Zhang Y, Liu K, et al. Carnosol suppresses patient-derived gastric tumor growth by targeting RSK2. Oncotarget. 2018;9(76):34200-34212.

[4]Alsamri H, El Hasasna H, Al Dhaheri Y, Eid AH, Attoub S, Iratni R. Carnosol, a Natural Polyphenol, Inhibits Migration, Metastasis, and Tumor Growth of Breast Cancer via a ROS-Dependent Proteasome Degradation of STAT3. Front Oncol. 2019;9:743.

[5]Vlavcheski F, Baron D, Vlachogiannis IA, MacPherson REK, Tsiani E. Carnosol Increases Skeletal Muscle Cell Glucose Uptake via AMPK-Dependent GLUT4 Glucose Transporter Translocation. Int J Mol Sci. 2018;19(5):1321.