CP-424174

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Chemical Structure| 210825-31-3 同义名 : -
CAS号 : 210825-31-3
货号 : A829204
分子式 : C22H29ClN2O4S
纯度 : 99%+
分子量 : 452.99
MDL号 : MFCD30537538
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(264.9 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Interleukin-1(IL-1) is a pro-inflammatory cytokine that plays a role in many acute and chronic human diseases, and elevated levels of IL-1 can be measured in human tissue or body fluids from patient with rheumatoid arthritis (RA), osteoarthritis, chronic obstructive pulmonary disease, asthma, inflammatory bowel and other diseases[1]. CP 424174 is identified as potent inhibitor of stimulus-coupled IL-1β post-translational processing. It blocks the formation of mature IL-1β without increasing the amount of procytokine. It inhibits ATP-induced proteolytic cleavage of pro-IL-1β, measured by secretion of the 17 kDa mature form of IL-1β, in LPS-primed human blood-derived monocytes when used at concentrations of 0.5 and 2.5 µM. CP 424,174 inhibits ATP-induced IL-1α and IL-1β production in LPS-primed mouse peritoneal macrophages (ED50s = 15 and 14 mg/kg, respectively)[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.21mL

0.44mL

0.22mL

11.04mL

2.21mL

1.10mL

22.08mL

4.42mL

2.21mL
参考文献

[1]Braddock, M. et al. Targeting IL-1 in inflammatory disease: new opportimotoes fro therapeutic intervention. Nature Review Drug Discovery. 2004. 3, 330-340.

[2]Perregaux, D. G. et al. Identification and Characterization of a Novel Class of Interleukin-1 Post-Translational Processing Inhibitors. ASPET. 2001. 299(1) 187-197.