Phillygenin

产品说明书

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Chemical Structure| 487-39-8 同义名 : (+)-Phillygenin; Epipinoresinol methyl ether; Sylvatesmin; Phillygenol
CAS号 : 487-39-8
货号 : A821594
分子式 : C21H24O6
纯度 : 99%+
分子量 : 372.41
MDL号 : MFCD01075148
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(67.13 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Phillygenin (Forsythigenol) is an active ingredient from Forsythia with many medicinal properties, such as antioxidant, reducing blood lipid, inhibition of low density lipoprotein oxidation. PHI (Phillygenin) attenuates CCl4(10% carbon tetrachloride)-induced liver fibrosis partly via modulating inflammation and gut microbiota[3]. PHI inhibited the inflammation and apoptosis of pulmonary epithelial cells by activating PPARγ signaling via downregulating MMP8[4]. Phillygenin inhibited the growth of SH-1-V1 cells and exhibited an IC50 of 6 µM. Phillygenin inhibited in vitro and in vivo cancer cell growth in drug-resistant human esophageal cancer cells, and these effects were mediated via apoptosis, ROS generation, mitochondrial membrane potential loss, and activation of the NF-kB signalling pathway[5]. PHI could inhibit the proliferation, migration, and EMT (epithelial-mesenchymal transition) of pancreatic cancer cells (PANC-1 and SW1990) and induce its apoptosis[6]. 179068-02-1 PHCCC
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.43mL

2.69mL

1.34mL

26.85mL

5.37mL

2.69mL
参考文献

[1]Ye LH, Li YX, et al. Determination of phillygenin in rat plasma by high-performance liquid chromatography and its application to pharmacokinetic studies. Eur J Drug Metab Pharmacokinet. 2013 Sep;38(3):201-7.

[2]Song W, Ao MZ, et al. Interaction between phillygenin and human serum albumin based on spectroscopic and molecular docking. Spectrochim Acta A Mol Biomol Spectrosc. 2012 Jan;85(1):120-6.

[3]Wang C, Ma C, Fu K, Gong LH, Zhang YF, Zhou HL, Li YX. Phillygenin Attenuates Carbon Tetrachloride-Induced Liver Fibrosis via Modulating Inflammation and Gut Microbiota. Front Pharmacol. 2021 Sep 21;12:756924

[4]Lin Y, Yang P. Phillygenin inhibits the inflammation and apoptosis of pulmonary epithelial cells by activating PPARγ signaling via downregulation of MMP8. Mol Med Rep. 2021 Nov;24(5):775

[5]He J, Wei W, Yang Q, Wang Y. Phillygenin Exerts In Vitro and In Vivo Antitumor Effects in Drug-Resistant Human Esophageal Cancer Cells by Inducing Mitochondrial-Mediated Apoptosis, ROS Generation, and Inhibition of the Nuclear Factor kappa B NF-κB Signalling Pathway. Med Sci Monit. 2019 Jan 25;25:739-745

[6]Li H, Chen M, Yang Z, Wang Q, Wang J, Jin D, Yang X, Chen F, Zhou X, Luo K. Phillygenin, a MELK Inhibitor, Inhibits Cell Survival and Epithelial-Mesenchymal Transition in Pancreatic Cancer Cells. Onco Targets Ther. 2020 Apr 3;13:2833-2842