TIC10 isomer

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Chemical Structure| 41276-02-2 同义名 : ONC201 isomer; TIC10 Analogue
CAS号 : 41276-02-2
货号 : A809132
分子式 : C24H26N4O
纯度 : 98+%
分子量 : 386.49
MDL号 : MFCD25976764
存储条件：

Pure form

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
靶点

  • Akt
描述 TIC10 isomer is an isomer of TIC10, a potent, orally active, and stable small molecule that transcriptionally induces TRAIL in a p53-independent manner and crosses the blood-brain barrier.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.59mL

0.52mL

0.26mL

12.94mL

2.59mL

1.29mL

25.87mL

5.17mL

2.59mL
参考文献

[1]Allen JE, Krigsfeld G, et al. Dual inactivation of Akt and ERK by TIC10 signals Foxo3a nuclear translocation, TRAIL gene induction, and potent antitumor effects. Sci Transl Med. 2013 Feb 6;5(171):171ra17.