Metoprolol

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Chemical Structure| 51384-51-1 同义名 : -
CAS号 : 51384-51-1
货号 : A807644
分子式 : C15H25NO3
纯度 : 98+%
分子量 : 267.36
MDL号 : MFCD00599534
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(392.72 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • β-adrenergic receptor
描述 Metoprolol is a selective β1 receptor blocker (Ki values are 47, 2960 and 10100 nM for β1, β2 and β3 adrenoceptors respectively) used in treatment of several diseases of the cardiovascular system, especially hypertension.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02012075 Heart Failure Phase 3 Unknown - China, Gansu ... 展开 >> Gansu Provincial Hospital Recruiting Lanzhou, Gansu, China China, Hubei Tongji Hospital Recruiting Wuhan, Hubei, China, 430030 China, Hunan The Second Xiangya Hospital of Central South University Recruiting Changsha, Hunan, China The Third Xiangya Hospital of Central South University Recruiting Changsha, Hunan, China China, Jiangsu Northern Jiangsu People's Hospital Recruiting Yangzhou, Jiangsu, China, 225001 China, Liaoning Shengjing Hospital of China Medical University Recruiting Shenyang, Liaoning, China, 110004 China, Zhejiang The First Affiliated Hospital of College of Medicine, Zhejiang University Recruiting Hangzhou, Zhejiang, China Taizhou Hospital Recruiting Taizhou, Zhejiang, China China Beijing ANZHEN Hospital Recruiting Beijing, China, 100029 Contact: Changsheng Ma, Professor    86-010-64456078    chshma@vip.sina.com    Principal Investigator: Changsheng Ma, Professor          China-Japan Friendship Hospital Recruiting Beijing, China, 100029 Xuan Wu Hospital affiliated to Capital Medical University Recruiting Beijing, China, 100053 Beijing Tongren hospital affiliated to Capital Medical University Recruiting Beijing, China 收起 <<
NCT01049009 - Completed - -
NCT01049009 High Blood Pressure Phase 4 Completed - United States, Georgia ... 展开 >> Emory University Atlanta, Georgia, United States, 30322 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.74mL

0.75mL

0.37mL

18.70mL

3.74mL

1.87mL

37.40mL

7.48mL

3.74mL
参考文献

[1]Yeh SY. Comparative anorectic effects of metaraminol and phenylephrine in rats. Physiol Behav. 1999 Dec 1-15;68(1-2):227-34.

[2]Shoji T, Sakurada S, et al. [Effect of beta-phenylethylamine derivatives on the central nervous system. II. Pharmacological effect of the intracerebral administration of metaraminol on the central nervous system] . Nihon Yakurigaku Zasshi. 1975 Jan;71(1):1-10. Japanese.