Hirsutine

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Chemical Structure| 7729-23-9 同义名 : -
CAS号 : 7729-23-9
货号 : A803763
分子式 : C22H28N2O3
纯度 : 98+%
分子量 : 368.47
MDL号 : MFCD01750089
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(284.96 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Hirsutine, an indole alkaloid isolated and purified from the herbs of Uncaria rhynchophylla, which can inhibits Late step in dengue virus lifecycle.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.71mL

0.54mL

0.27mL

13.57mL

2.71mL

1.36mL

27.14mL

5.43mL

2.71mL
参考文献

[1]Lou C, Yokoyama S, et al. Selective anticancer activity of hirsutine against HER2‑positive breast cancer cells by inducing DNA damage. Oncol Rep. 2015 Apr;33(4):2072-6.

[2]Yano S, Horiuchi H, et al. Ca2+ channel blocking effects of hirsutine, an indole alkaloid from Uncaria genus, in the isolated rat aorta. Planta Med. 1991 Oct;57(5):403-5.