Annonacin
产品说明书
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同义名 : | - |
| CAS号 : | 111035-65-5 | |
| 货号 : | A802275 | |
| 分子式 : | C35H64O7 | |
| 纯度 : | 97% | |
| 分子量 : | 596.88 | |
| MDL号 : | - | |
| 存储条件： |
Pure form In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Annonacin, a natural product isolated and purified from the herbs of Annona glabra, is mitochondrial complex I inhibitor, reported to be more toxic than rotenone to mesencephalic neurons, and can cause significant cell death in various cancer cell lines. Annonacin induces growth arrest and apoptosis in ERα-related pathways in MCF-7 cells, attenuates MCF-7 xenograft tumor growth while inhibiting ERα, cyclin D1 and Bcl-2 protein expressions in nude mice. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.68mL 0.34mL 0.17mL |
8.38mL 1.68mL 0.84mL |
16.75mL 3.35mL 1.68mL |
| 参考文献 |
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