Oxidopamine HCl

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Chemical Structure| 28094-15-7 同义名 : 6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride; Oxidopamine hydrochloride
CAS号 : 28094-15-7
货号 : A798419
分子式 : C8H12ClNO3
纯度 : 98%
分子量 : 205.64
MDL号 : MFCD00012895
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(413.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(486.29 mM)，配合低频超声助溶
生物活性
描述 Oxidopamine hydrochloride is a neurotoxic synthetic organic compound, selectively destroys dopaminergic and noradrenergic neurons in the brain.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01108029 Parkinson's Disease ... 展开 >> Gait Disorders, Neurologic 收起 << Phase 4 Completed - France ... 展开 >> Devos Lille, France, 59037 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.86mL

0.97mL

0.49mL

24.31mL

4.86mL

2.43mL

48.63mL

9.73mL

4.86mL
参考文献

[1]Fujita H, Ogino T, et al. Cell-permeable cAMP analog suppresses 6-hydroxydopamine-induced apoptosis in PC12 cells through the activation of the Akt pathway. Brain Res. 2006 Oct 3;1113(1):10-23.

[2]Soto-Otero R, Mendez-Alvarez E, et al. Autoxidation and neurotoxicity of 6-hydroxydopamine in the presence of some antioxidants: potential implication in relation to the pathogenesis of Parkinson's disease. J Neurochem. 2000 Apr;74(4):1605-12.