Difluprednate
产品说明书
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同义名 : | W-6309 |
| CAS号 : | 23674-86-4 | |
| 货号 : | A794471 | |
| 分子式 : | C27H34F2O7 | |
| 纯度 : | 98% | |
| 分子量 : | 508.55 | |
| MDL号 : | MFCD00214273 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(491.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Difluprednate is a corticosteroid, approved difluprednate for the treatment of post-operative ocular inflammation and pain. Topical difluprednate is potentially effective and safe in preventing graft rejection after penetrating keratoplasty[3]. Difluprednate is effective for managing ocular manifestations of Harada's disease[4]. Difluprednate is also an effective treatment for patients with severe pseudophakic cystoid macular edema[5]. Difluprednate 0.05% four times daily showed safety and efficacy profiles similar to prednisolone acetate 1% four times daily in children 0-3 years undergoing cataract surgery[6]. Two months after initiation of topical difluprednate, fluorescein angiography demonstrated resolution of retinal vasculitis in both treated eyes[7]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT03626376 | Herpes Simplex Virus Keratitis | Phase 4 | Not yet recruiting | October 2019 | United States, New York ... 展开 >> New York University School of Medicine Not yet recruiting New York, New York, United States, 10016 Contact: Stacy Mach 929-455-5539 Stacy.Mach@nyumc.org Principal Investigator: Leela Raju, MD 收起 << |
| NCT01541527 | - | Withdrawn(Promoter's change) | - | France ... 展开 >> CHU de Montpellier- Centre administratif André Benech Montpellier, France, 3400 收起 << | |
| NCT02215863 | Influenza Str... 展开 >>eptococcus Pneumoniae 收起 << | Phase 4 | Completed | - | Korea, Republic of ... 展开 >> Korea University Ansan Hospital Ansan, Korea, Republic of Hallym University Gangnam Sacred Hospita Seoul, Korea, Republic of Catholic University Medical College, St. Vincent's Hospital Suwon, Korea, Republic of 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.97mL 0.39mL 0.20mL |
9.83mL 1.97mL 0.98mL |
19.66mL 3.93mL 1.97mL |
| 参考文献 |
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