Pinacidil

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Chemical Structure| 60560-33-0 同义名 : P-1134
CAS号 : 60560-33-0
货号 : A793489
分子式 : C13H19N5
纯度 : 99%+
分子量 : 245.32
MDL号 : MFCD00153861
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(428.01 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 Pinacidil is a strong potassium channel opener and antihypertensive agent that hyperpolarizes vascular smooth muscle by activating K+-channels. It significantly enhances reperfusion function and cardiac compliance and exhibits direct cardioprotective effects[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.08mL

0.82mL

0.41mL

20.38mL

4.08mL

2.04mL

40.76mL

8.15mL

4.08mL
参考文献

[1]Grover GJ, et al. Anti-ischemic effects of the potassium channel activators pinacidil and cromakalim and the reversal of these effects with the potassium channel blocker glyburide. J Pharmacol Exp Ther. 1989;251(1):98-104.