Bentamapimod

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Chemical Structure| 848344-36-5 同义名 : AS 602801
CAS号 : 848344-36-5
货号 : A793130
分子式 : C25H23N5O2S
纯度 : 98%
分子量 : 457.55
MDL号 : MFCD08272350
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 7 mg/mL(15.3 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • JNK1

    JNK1, IC50:80 nM

  • JNK2

    JNK2, IC50:90 nM

  • JNK3

    JNK3, IC50:230 nM
描述 Bentamapimod (AS 602801) induces cell death in a dose-dependent manner across various cancer cell lines including human pancreatic, non-small cell lung, ovarian cancer, and glioblastoma cells, without affecting the viability of normal human fibroblasts. It also hinders the self-renewal and tumor-initiating capabilities of cancer stem cells that survive treatment with Bentamapimod (AS 602801)[2].
作用机制 AS-602801 is an ATP competitive JNK inhibitor.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.19mL

0.44mL

0.22mL

10.93mL

2.19mL

1.09mL

21.86mL

4.37mL

2.19mL
参考文献

[1]Zhao J, Pei G. Evoking plasmin for beta-amyloid clearance. Cell Res. 2008 Aug;18(8):803-4.

[2]Kellici TF, Pilka ES, Bodkin MJ. Therapeutic Potential of Targeting Plasminogen Activator Inhibitor-1 in COVID-19. Trends Pharmacol Sci. 2021 Jun;42(6):431-433.