AMD 3465 6HBr

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Chemical Structure| 185991-07-5 同义名 : GENZ-644494 hexahydrobromide; AMD 3465 hexahydrobromide; AMD 3465 (hydrobromide)
CAS号 : 185991-07-5
货号 : A790755
分子式 : C24H44Br6N6
纯度 : 98%
分子量 : 896.07
MDL号 : MFCD20926342
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(55.8 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 35 mg/mL(39.06 mM)
生物活性
靶点

  • CXCR4
描述 AMD 3465 hexahydrobromide is a potent, selective CXCR4 antagonist and exhibits 8-fold higher affinity than AMD 3100 and inhibits SDF-1α-ligand binding (Ki = 41.7 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.12mL

0.22mL

0.11mL

5.58mL

1.12mL

0.56mL

11.16mL

2.23mL

1.12mL
参考文献

[1]Bodart V, Anastassov V, et al. Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4. Biochem Pharmacol. 2009 Oct 15;78(8):993-1000.

[2]Rosenkilde MM, Gerlach LO, et al. Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists in the CXCR4 chemokine receptor. J Biol Chem. 2007 Sep 14;282(37):27354-65. Epub 2007 Jun 28.