Quinestrol
产品说明书
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同义名 : | 炔雌醇环戊醚 ;W-3566; Ethynyl Estradiol-3-cyclopentyl ether; Estradiol 3 Cyclopentyl Ether; Ethinyl; Eston; Plestrovis; Estrovister; Quinestrolum; Estrovis; Ethinylestradiol 3-cyclopentyl ether |
| CAS号 : | 152-43-2 | |
| 货号 : | A786551 | |
| 分子式 : | C25H32O2 | |
| 纯度 : | 98% | |
| 分子量 : | 364.52 | |
| MDL号 : | MFCD00079189 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 250 mg/mL(685.83 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Quinestrol is a synthetic estrogen, used in hormone replacement therapy, and occasionally to treat breast cancer and prostate cancer. The weight of epididymides and seminal vesicles decreased significantly on days 8 and 22 in quinestrol/DES-treated (Diethylstilbestrol) mice, with extensive histological changes in the seminiferous tubules. The anti-fertility effects on male mice given quinestrol were of shorter duration than for those receiving DES at the dose of 1 mg/kg body weight[3]. Quinestrol causes reversible toxic effects in the form of oxidative stress, increased lytic enzyme activity and decreased steroidogenesis which may further lead to testicular damage thereby inhibiting reproductive function[4]. Normal male vocal behavior during sexual interactions could be retained or even reinforced after quinestrol treatment. The treated male mice were more attractive to the female mice than the controls[5]. The testicular weight and seminiferous tubular area gradually declined with increasing dosages of quinestrol to 50 and 100mg/kg. Rarefied germ cells showed irregular distributions in the seminiferous tubules of mice treated with 50 and 100mg/kg quinestrol. The number of germ cells expressing caspase-3, p53, Bax and FasL significantly increased whereas cells expressing Bcl-2 significantly decreased in groups treated with 50 and 100mg/kg quinestrol compared with the control. Quinestrol stimulates oxidative stress to induce apoptosis in spermatogenic cells through the mitochondrial and death receptor pathways in adult male mice[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.74mL 0.55mL 0.27mL |
13.72mL 2.74mL 1.37mL |
27.43mL 5.49mL 2.74mL |
| 参考文献 |
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