SU 5402

产品说明书

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Chemical Structure| 215543-92-3 同义名 : -
CAS号 : 215543-92-3
货号 : A781751
分子式 : C17H16N2O3
纯度 : 98%
分子量 : 296.32
MDL号 : MFCD08235144
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 30 mg/mL(101.24 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
靶点

  • VEGFR2

    VEGFR2, IC50:20 nM

  • FGFR1

    FGFR1, IC50:30 nM
描述 SU5402 is potent and selective vascular endothelial growth factor receptor (VEGFR) and fibroblast growth factor receptor (FGFR) inhibitor.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
mouse HER14 cells Function assay Inhibition of EGFR in mouse HER14 cells assessed as inhibition of EGF-stimulated Shc phosphorylation by immunoblotting 9139660
mouse NIH/3T3 cell Function assay Inhibition of acidic FGF-stimulated FGFR1 tyrosine autophosphorylation in mouse NIH/3T3 cells by immunoblottingm, IC50=10 μM 9139660
mouse NIHIR cells Function assay Inhibition of insulin-stimulated insulin receptor beta subunit autophosphorylation in mouse NIHIR cells 9139660
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.37mL

0.67mL

0.34mL

16.87mL

3.37mL

1.69mL

33.75mL

6.75mL

3.37mL
参考文献

[1]Lo AK, Dawson CW, et al. Activation of the FGFR1 signalling pathway by the Epstein-Barr virus-encoded LMP1 promotes aerobic glycolysis and transformation of human nasopharyngeal epithelial cells. J Pathol. 2015 Oct;237(2):238-48.

[2]Sun L, Tran N, et al. Design, synthesis, and evaluations of substituted 3-[(3- or 4-carboxyethylpyrrol-2-yl)methylidenyl] indolin-2-ones as inhibitors of VEGF, FGF, and PDGF receptor tyrosine kinases. J Med Chem. 1999 Dec 16;42(25):5120-30.