Ro 48-8071

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Chemical Structure| 161582-11-2 同义名 : -
CAS号 : 161582-11-2
货号 : A779028
分子式 : C23H27BrFNO2
纯度 : 99+%
分子量 : 448.37
MDL号 : MFCD18432703
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
生物活性
描述 Ro 48-8071 is an inhibitor of OSC (Oxidosqualene cyclase; IC50=6.5 nM) that has low-density lipoprotein (LDL) cholesterol lowering activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.15mL

2.23mL

1.12mL

22.30mL

4.46mL

2.23mL
参考文献

[1]Liang Y, Mafuvadze B, et al. Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells. Onco Targets Ther. 2016 May 30;9:3223-32.

[2]Morand OH, Aebi JD, et al. Ro 48-8.071, a new 2,3-oxidosqualene:lanosterol cyclase inhibitor lowering plasma cholesterol in hamsters, squirrel monkeys, and minipigs: comparison to simvastatin. J Lipid Res. 1997 Feb;38(2):373-90.