KX1-004

产品说明书

Print
Chemical Structure| 518058-84-9 同义名 : -
CAS号 : 518058-84-9
货号 : A769419
分子式 : C16H13FN2O2
纯度 : 97%
分子量 : 284.29
MDL号 : MFCD25977063
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(369.35 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
生物活性
描述 KX1-004 emerges is a potent non-ATP competitive inhibitor of Src-PTK, with an IC50 value of 40 μM, offering a novel approach to protect the cochlea from hazardous noise exposure and prevent noise-induced hearing loss (NIHL)[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.18mL

7.04mL

3.52mL
参考文献

[1]Harris KC, et al. Prevention of noise-induced hearing loss with Src-PTK inhibitors. Hear Res. 2005 Oct;208(1-2):14-25.

[2]Bielefeld EC, et al. A comparison of the protective effects of systemic administration of a pro-glutathione drug and a Src-PTK inhibitor against noise-induced hearing loss. Noise Health. 2005 Oct-Dec;7(29):24-30.