Rubitecan
产品说明书
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同义名 : | 鲁比特康 ;RFS 2000; Camptogen; 9-nitro-CPT; Abbreviation:9-nitro-20(S)-Camptothecin; Partaject rubitecan; Partaject Orathecin; 9-NC; 9-Nitrocamptothecin |
| CAS号 : | 91421-42-0 | |
| 货号 : | A759395 | |
| 分子式 : | C20H15N3O6 | |
| 纯度 : | 99%+ | |
| 分子量 : | 393.35 | |
| MDL号 : | MFCD06656294 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 60 mg/mL(152.54 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Rubitecan (RFS 2000), a Camptothecin derivative, is an orally active topoisomerase I inhibitor with broad antitumor activity, inducing protein-linked DNA single-strand breaks, thereby blocking DNA and RNA synthesis in dividing cells [1][2][3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01833286 | Hepatocellular Carcinoma ... 展开 >> Surgery Ablation 收起 << | Phase 3 | Not yet recruiting | July 2019 | China, Guangdong ... 展开 >> Sun Yat-sen University Cancer Center Not yet recruiting Guangzhou, Guangdong, China, 510060 Contact: minshan chen, M.D. 8620-87343117 ext 8620-87343117 chminsh@mail.sysu.edu.cn Contact: yaojun zhang, M.D. 8620-87343121 zhyaojun@mail.sysu.edu.cn Principal Investigator: minshan chen, M.D. 收起 << |
| NCT00554905 | Hepatocellular Carcinoma ... 展开 >> Liver Cancer 收起 << | Phase 4 | Unknown | June 2009 | China, Guangdong ... 展开 >> Department of Hepatobilliary Surgery, Cancer Center, Sun Yat-sen University Recruiting Guangzhou, Guangdong, China, 510060 Contact: Min-Shan Chen, Doctor 86-20-87343117 ext 86-20-87343117 Chminsh@mail.sysu.edu.cn Principal Investigator: Min-Shan Chen, Doctor 收起 << |
| NCT02426450 | Hepatocellular Carcinoma | Phase 2 | Unknown | April 2017 | China, Guangdong ... 展开 >> Zhen-Wei Peng Guangzhou, Guangdong, China, 510080 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.54mL 0.51mL 0.25mL |
12.71mL 2.54mL 1.27mL |
25.42mL 5.08mL 2.54mL |
| 参考文献 |
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